It’s a boy – Royal baby latest
Harry and Meghan's baby will be seventh in line to the throne and the Queen and the Duke of Edinburgh's eighth great-grandchild, and a fourth grandchild for the Prince of Wales.
Ahead of the birth, the duke and duchess made a personal decision to keep the arrangements private, amid speculation they had opted for a home birth at their new home Frogmore Cottage, close to the Queen's Windsor Castle home.
Meghan was last seen on an official engagement on March 19 when she signed a book of condolences in London with Harry for the victims of the Christchurch terror attack.
Here's the Buckingham Palace statement in full:
"Her Royal Highness The Duchess of Sussex was safely delivered of a son at 0526hrs.
"The baby weighs 7lbs 3oz.
"The Duke of Sussex was present for the birth.
"The Queen, The Duke of Edinburgh, The Prince of Wales, The Duchess of Cornwall, The Duke and Duchess of Cambridge, Lady Jane Fellowes, Lady Sarah McCorquodale and Earl Spencer have been informed and are delighted with the news.
"The Duchess's mother, Doria Ragland, who is overjoyed by the arrival of her first grandchild, is with Their Royal Highnesses at Frogmore Cottage.
"Her Royal Highness and her child are both doing well."
The Duke of Sussex was present for the birth which happened at 5.26am.
The Queen, The Duke of Edinburgh, The Prince of Wales, The Duchess of Cornwall, The Duke and Duchess of Cambridge, Lady Jane Fellowes, Lady Sarah McCorquodale and Earl Spencer have been informed and are "delighted with the news", the palace said.
The statement added that the Duchess's mother Doria Ragland "who is overjoyed by the arrival of her first grandchild"was with the couple at Frogmore Cottage.
The palace said the name of the baby would be announced in due course.
The duke and duchess's Instagram account @SussexRoyal also announced the birth saying: "It's a boy! Their Royal Highnesses the Duke and Duchess of Sussex are overjoyed to announce the birth of their child."
A beaming Harry said: "It's been the most amazing experience I could ever have possibly imagined.
"How any woman does what they do is beyond comprehension. But we're both absolutely thrilled.
"We're both absolutely thrilled and so grateful for all the love and support from everybody out there, it's been amazing, so we just wanted to share this with everybody."
Harry said the couple were "still thinking about names" for their son.
He said: "The baby was a little bit overdue so we've had a little bit of time to think about it.
"That's the next bit."
He said he planned to make another announcement in two days' time "so everyone can see the baby".
Harry added: "I haven't been at many births.
"This is definitely my first birth - it was amazing, absolutely incredible.
"I'm so incredibly proud of my wife.
"And as every father and parent would say, your baby is absolutely amazing.
"But this little thing is absolutely to-die-for so I'm absolutely over the moon."